Diabetic Peripheral Neuropathy

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Diabetes is a debilitating disease that destroys the human body. Diabetic neuropathy affects the peripheral nerves, including the autonomic nervous system, motor neurons and pain fibers, and since all organs are connected within the body through the nervous system, potentially the entire body. Diabetic neuropathy results from injuries to the small blood vessels which supply blood to the nerves.

Symptoms to List in a Diabetic Peripheral Neuropathy Research Paper

There are a number of potential symptoms of diabetic neuropathy including:

• numbness
• dizziness
• muscular weakness
• difficulty with speech
• urinary incontinence
• erectile dysfunction

Diabetic neuropathy develops through four factors: micro vascular disease, protein kinase C (PKC), advanced glycenated end product and polyol pathways. However, different nerves are affected in different ways.

With sensorimotor polyneuropathy the long nerve fibers that control reflexes are affected, frequently beginning to appear as numbness or tingling in the toes, before spreading upwards. The disease progresses throughout the body, resulting in lost muscular function.

Neuropathy Treatment

Diabetic individuals who experience foot or leg pain are frequently diagnosed with neuropathy, and there are very little options in the way of treatment. Most treatment focuses on pain reduction. The FDA has currently approved three drugs for the treatment of diabetic neuropathy: duloxetine, an antidepressant, pregabalin, an anticoagulant and tapentadol ER, an opioid.